2015.6
About Instruments Today No. 203
Application of Chemical Analysis
Laser-Based Molecular Imaging Mass Spectrometry [ 下載 PDF ]
Hung Su, Jentaie Shiea
Due to the rise of proteomics and metabolomics, mass spectrometry has played an important role in many areas. One innovative application of mass spectrometry is imaging mass spectrometry (IMS) which is a label-free bioanalytical technique. The molecular imaging obtained by mass spectrometric analysis directly reveals distribution of specific biochemical compounds on clinical tissues. Combining IMS with pathological diagnosis will be helpful in discovering cancer-related biomarkers. In this paper, laser-based molecular imaging mass spectrometry will be introduced.
Introduction of High Performance Integrated-System Photocatalytic Reactor [ 下載 PDF ]
Hung Ji Huang
High performance integrated-system photocatalytic reactor combined the ideas from modern optics, microuidics and frontier nano-technology to have enhanced processing efficiency. The inherent technical advantages of integratedsystem photocatalytic reactor result in important developments on chemical engineering in the recent years. In this paper, several improvements are discussed in this paper. The surface-area with deposited photocatalyst was increased in limited-volume for chemical reaction. Higher mass transfer rate and higher processing capability was achieved. Excitation with wide-band light and higher light-harvest were also did for enhancing chemical reaction. The integrated-system photocatalytic reactor is a faster and better performance technology in green chemistry.
Application of Lidar Network with Cloud Computing [ 下載 PDF ]
Chih-Wei Chiang, Hong-Wei Chiang, Shu-Huang Sun, Chien Lin Chen, Liang Hsuan Su, Yi-Hsi Lee
An effort has been made by EPA (Environmental Protection Administration) to prevent deterioration of air quality. However, tracking pollution source, the dispersion and types of pollution are rather difficult especially when air pollution emergencies occur. Therefore, the application of this new developing technique, combined the newly 3-D scanning LIDAR (light detection and ranging) system with GIS (geographic information system) and fast integration of information by cloud computing technique will be useful to enhance the effectiveness of inspection and to strengthen the capability of the environmental monitoring.
Development of an In-situ Chromatic Confocal Measuring System for Precision Microscopic Surface Profilometry [ 下載 PDF ]
Liang-Chia Chen, Chang-Min Lin, Shyh-Tsong Lin, Duc-Trung Nguyen
This article presents the development of an in-situ chromatic confocal line-scan measuring system using wavelength-resolved chromatic confocal principle and the analysis and optimization of volumetric errors of the developed measuring platform to achieve one-shot and high-accuracy microscopic surface profilometry in an integrated three-axis scanning instrument. Optical confocal measurement for microscopic surface profilometry has become extremely important due to its high longitudinal measurability range and excellent vertical resolution. A chromatic confocal probe employing broadband light as well as a chromatic dispersion objective is integrated with a 3 axis scanning platform to establish in-situ 3-D profile measurement in one-shot manner. The developed confocal system is designed and analyzed to characterize the system volumetric errors, such as positioning errors, angular deviation, moving straightness and squareness between the three axes. It is implemented by measuring and analyzing of 21 volumetric errors in 3-axis system for system optical alignment and installation, thus the volumetric errors can be minimized by optimal machine alignment and integration. Our experimental tests on standard targets have verified that the developed system can perform the measurement precision with one standard deviation to be controlled within 0.1 µm. Some industrial parts, such as semiconductor wafers, have been also verified with its effectiveness in sub-micro scale measurement and reconstruction of 3-D microscopic surface profiles.
Ultra-High Precision Measurement and Positioning System [ 下載 PDF ]
En-Te Hwu, Chung-Hsiang Cheng, Ching-Hsiu Chen, Wei-Min Wang, Huang-Hang Chen
Institute of Physics, Academia Sinica develops scanning probe microscopy for 2 decades, which generates ultra-high precision measurement and positioning techniques. Those techniques can be custom designed for multi-axes linear, angular, rotational measurement and actuation as a core of precision instruments. In this article, we will introduce spectrometer, laser interferometer, laser auto-collimator systems for precision measurements and nano-scale positioning systems for precision positioning.
A Magic Carpet toward Future: Introduction to 2D-Materials and Large-Area Synthetic Technologies [ 下載 PDF ]
Zhen-Yu Juang
The age of 2D-materials was boosted by the discovery of the first thermal dynamical stable 2D-material, i.e. graphene, using Scotch tape since 2004. In order to match the requirement of mass production from industry, the synthetic methods have been wide investigated. In the beginning of this paper, an introduction to 2D-materials will be addressed followed by the remarkable synthetic method of hot-wall chemical vapor deposition (HW-CVD). The strength and weakness of HW-CVD will be discussed. After that, the state-of-the-art cold-wall chemical vapor deposition (HW-CVD) for the synthesis of wafer-scaled 2D-materials will be introduced. This paper provides audience a vision and insight to 2D-materials for future applications.
Combining Hyperthermia by Using Electromagnetic Waves with Chemotherapy for the Treatment of Cancer [ 下載 PDF ]
Kung-Shan Cheng
The heating systems by using electromagnetic wave can heat the cells inside human body, and thus are capable of destroying the cancerous cells. In addition, they can be simultaneously used with systemic chemotherapy to noninvasively accomplish better therapeutic effects by synergic effects. Nevertheless, it requires multidisciplinary professional knowledge to be capable of focusing electromagnetic energy on cancerous site by external energy sources, so that minimal portion of healthy cells is damaged while the cancerous site is destroyed. This article introduced these required knowledge with the hope that more professionals would participate in this area and thus benefit the patients having cancer.
The Study of Bipolar Sawtooth-Like Waveform Converter as PZT Driver [ 下載 PDF ]
Tai-Shan Liao
It does not require high-precision mechanical components, also free from dust and other disturbances because the apparatus with Stick-slip effect device depends on the platform and supports static and dynamic friction material characteristics for very wide application of piezoelectric displacement devices. Unipolar signal to drive the piezoelectric component under long-term use will produce polarization problem and cause displacement deviation. It is usually using the bi-directional signal to drive a piezoelectric components because the bi-directional signal with a voltage of opposite polarity can offset the polarization in order to solve doubts of polarized effect of piezoelectric components. Therefore, a bipolar sawtooth-like waveform converter as piezoelectric driver was presented. Circuit design and test results described in this article. This technique can be used by scanning probe microscope, or scanning tunneling microscope in the future.
